Critical roles of junctophilin-2 in T-tubule and excitation–contraction coupling maturation during postnatal development
نویسندگان
چکیده
منابع مشابه
Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.
AIMS Transverse tubules (TTs) provide the basic subcellular structures that facilitate excitation-contraction (EC) coupling, the essential process that underlies normal cardiac contractility. Previous studies have shown that TTs develop within the first few weeks of life in mammals but the molecular determinants of this development have remained elusive. This study aims to elucidate the role of...
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Roles of junctophilin-2 in muscle hypertrophy
Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea, Department of Pharmacology and Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 110-799, Korea, Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea, Department of Physiology and Biophysics, UMDNJ-Robert Wood Jo...
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Cardiac myocytes from the mdx mouse, the mouse model of Duchenne muscular dystrophy, exhibit t-tubule disarray and increased calcium sparks, but a unifying molecular mechanism has not been elucidated. Recently, improper trafficking of junctophilin-2 on an altered microtubule network caused t-tubule derangements and calcium mishandling in a pressure-overload heart failure model. Mdx cardiac myoc...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2013
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvt180